Influenza A virus polymerase co-opts distinct sets of host proteins for RNA transcription or replication - PubMed
4 days ago
- #host-pathogen interactions
- #influenza virus
- #antiviral targets
- Influenza A virus polymerase uses different host proteins for RNA transcription and replication.
- The study identifies distinct sets of host proteins interacting with the polymerase during transcription or replication.
- HMGB2 and RUVBL2 are characterized as replication cofactors, while RPAP2 is identified as a transcription cofactor.
- Comparative proteomics is highlighted as a method to uncover virus-host interactions regulating specific viral life cycle stages.