Development and characterization of anti-CXCR4 chimeric antigen receptor T cells - PubMed
3 days ago
- #CAR-T
- #Leukemia
- #CXCR4
- Development of anti-CXCR4 chimeric antigen receptor (CAR) T cells for treating Acute Myeloid Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL).
- CXCR4 plays a key role in normal hematopoiesis and leukemogenesis by retaining cells in the bone marrow niche.
- Anti-CXCR4 CAR-T cells show potent activity against leukemic cell lines in vitro without affecting other T cells.
- Decreased CXCR4 protein expression in CAR-positive populations suggests a pathway for T cell survival.
- Potential application as a dual HSCT-conditioning and anti-leukemia agent.