Status of non-thiamine B-vitamins in children with septic shock from a lower middle-income country: a case-control study - PubMed
5 hours ago
- #Pediatrics
- #B-vitamins
- #Septic shock
- The study examined riboflavin, niacin, pyridoxine, folate, and cobalamin levels in children with septic shock in an LMIC, compared to sibling and external controls.
- Children with septic shock had significantly lower plasma levels of all five B-vitamins compared to sibling controls.
- Sibling controls also showed lower B-vitamin levels than external controls, indicating pre-existing deficiencies likely due to shared family nutrition.
- Among patients, non-survivors had lower riboflavin and pyridoxine levels, while folate levels were higher compared to survivors.
- The findings suggest septic shock exacerbates pre-existing B-vitamin deficiencies, highlighting a potential need for adjunctive B-vitamin therapy in pediatric septic shock in LMICs.