Air Pollution and Incident Cardiovascular Disease: Modification by Genetic Susceptibility and the Mitigating Role of Physical Activity - PubMed
5 hours ago
- #cardiovascular-disease
- #genetic-susceptibility
- #air-pollution
- Study examines the link between air pollution, genetic predisposition, and physical activity on cardiovascular disease (CVD) risk.
- Involved 330,481 UK Biobank participants without baseline CVD, tracking incident CVD over a median 11.8-year follow-up.
- Found positive associations between various air pollutants (PM2.5, PM10, nitrogen oxides, nitrogen dioxide) and increased CVD risk.
- Participants with high air pollution exposure and high genetic risk had the highest CVD incidence (HR: 1.666).
- Physical activity (PA) showed protective effects, but benefits were reduced in high pollution and high genetic risk groups.
- Highlights the need for integrating environmental control with personalized prevention strategies to mitigate CVD risk.