Water-Soluble Anthocyanins from Vaccinium myrtillus L. Alleviate Diabetic Kidney Disease by Targeting ALOX15-Mediated Lipid Peroxidation - PubMed
6 hours ago
- #Ferroptosis
- #Anthocyanins
- #Diabetic Kidney Disease
- A water-soluble anthocyanin-rich bilberry extract (VmE) alleviates diabetic kidney disease (DKD) in a mouse model.
- Key bioactive components in VmE are delphinidin-3-O-glucoside (Dp3Glc) and cyanidin-3-O-glucoside (Cy3Glc).
- Dp3Glc and Cy3Glc directly bind to ALOX15, inhibiting lipid peroxidation and reducing ferroptosis in renal cells.
- VmE improves renal function, reduces tubulointerstitial injury, and restores metabolic homeostasis.
- The study supports developing VmE as a nutraceutical for DKD, linking traditional use with modern mechanisms.