APOE-mediated sex differences in microvascular pathology and AD-associated proteinopathies in the medial temporal lobe - PubMed
4 hours ago
- #Alzheimer's disease
- #APOE
- #sex differences
- Study examines APOE-mediated sex differences in microvascular pathology and AD-associated proteinopathies in the medial temporal lobe (MTL).
- Higher cerebral amyloid angiopathy (CAA) burden in women linked to lower Aβ plaques but higher tau tangle density.
- No significant interaction found between arteriolosclerosis and AD-associated proteinopathies.
- Women under 75 with APOE ε4 allele showed higher Aβ plaque burden compared to non-carriers.
- Findings highlight complex sex-specific effects on microvascular and AD-related pathologies in the MTL.