Revealing the Antagonistic Interactions of Faecalibacterium prausnitzii and Bacteroides fragilis in Colorectal Cancer - PubMed
3 days ago
- #Gut Microbiota
- #Picolinic Acid
- #Colorectal Cancer
- Study reveals antagonistic interactions between Faecalibacterium prausnitzii and Bacteroides fragilis in colorectal cancer (CRC).
- Faecalibacterium prausnitzii metabolizes tryptophan into picolinic acid (PIA), which antagonizes enterotoxigenic B. fragilis-mediated tumor progression.
- Enterotoxigenic B. fragilis up-regulates genes TCERG1 and CKAP2, associated with poor differentiation and recurrence in CRC.
- PIA induces tumor cell apoptosis by down-regulating TCERG1 and CKAP2.
- A tryptophan-rich diet elevates circulating PIA levels, suggesting potential as an anticancer dietary intervention.
- The F. prausnitzii-PIA-TCERG1/CKAP2 axis is identified as a key regulatory pathway in CRC.