Mechanisms and disease relevance of mitochondrial translation in humans - PubMed
7 days ago
- #ribosome biogenesis
- #mitochondrial translation
- #oxidative phosphorylation
- Human mitochondrial ribosomes (mitoribosomes) synthesize 13 mitochondrial-encoded proteins for oxidative phosphorylation.
- Recent studies reveal intricate regulation of mitochondrial translation initiation, elongation, termination, ribosome biogenesis, and quality control mechanisms.
- High-resolution structural studies and mitoribosome profiling provide insights into regulatory networks of mitochondrial translation.
- Mitochondrial translation dysfunction has pathological consequences, including antibiotic-induced ribosome stalling with varying effects.
- Mitochondrial protein synthesis plays emerging roles in cancer and immunity, with clinical relevance.
- Future directions include in vitro reconstitution of mitochondrial translation, mitochondrial DNA gene editing, and therapeutic applications.