Clinicopathologic characteristics of early-onset breast cancer among unselected young Black women - PubMed
4 hours ago
- #Breast Cancer Genetics
- #Black Women Health
- #Early-Onset Breast Cancer
- Study focused on early-onset breast cancer in young Black women (≤50 years) recruited via state cancer registries.
- Genetic testing revealed 15.3% had germline pathogenic/likely pathogenic variants, predominantly in BRCA1 (7.7%), BRCA2 (4.5%), and PALB2 (0.9%).
- BRCA1 carriers showed a high prevalence of triple-negative breast cancer (75.5%) compared to sporadic cases (23.6%).
- Family history of breast cancer was significantly more common in BRCA1, BRCA2, and PALB2 carriers.
- Most BRCA1-associated cancers occurred by age 40 (52.8%), while other genes had more even age distributions.
- Findings highlight distinct clinicopathologic traits across hereditary breast cancer genes, emphasizing universal genetic testing importance.