Revitalizing mitochondrial quality control: targeting mitochondria-derived vesicles in Parkinson's disease - PubMed
18 hours ago
- #Parkinson's disease
- #mitochondria-derived vesicles
- #mitochondrial quality control
- Parkinson's disease (PD) is characterized by loss of dopaminergic neurons and lacks disease-modifying therapies.
- Impaired mitochondrial quality control (MQC), including mechanisms like biogenesis, dynamics, mitophagy, and mitochondria-derived vesicles (MDVs), is a central driver of PD pathogenesis.
- MDVs are small vesicles that transport damaged mitochondrial components to lysosomes for degradation, offering a rapid, localized alternative to mitophagy.
- MDVs also function in inter-organelle signaling and intercellular communication, influencing neuronal homeostasis.
- Disruption of MDV processes contributes to mitochondrial dysfunction and neurodegeneration in PD.
- Targeting MDV pathways may provide novel diagnostic and therapeutic strategies to modify PD progression.