Equine arteritis virus Nsp10 promotes MAVS proteasomal degradation via E3 ligases Smurf1/MARCH5 - PubMed
2 hours ago
- #MAVS degradation
- #EAV
- #innate immunity evasion
- EAV nsp10 protein interacts with MAVS and promotes its degradation via proteasome.
- E3 ubiquitin ligases Smurf1 and MARCH5 are recruited by nsp10 to ubiquitinate MAVS.
- Nsp10 dimerization, mediated by zinc finger motifs, is essential for MAVS degradation.
- Key amino acid residues in nsp10 (D249, S287, S1/F39/N41) are critical for binding MAVS, Smurf1, and MARCH5.
- This mechanism represents a novel immune evasion strategy by EAV, targeting the MAVS signaling pathway.