MyoRep: A Novel Reporter System to Detect Early Muscle Atrophy In Vitro and In Vivo - PubMed
4 hours ago
- #reporter system
- #muscle atrophy
- #cancer cachexia
- MyoRep is a reporter system designed to detect early pathological muscle atrophy, distinguishing it from physiological atrophy.
- The study identifies GREDEL as the most effective promoter for anticipating atrophy, showing sensitivity to cachexia and denervation without responding to fasting.
- MyoRep mice demonstrated early detection of muscle atrophy in cancer and denervation models, and the system was validated for testing anti-atrophic drugs like musclin.