Natural killer cell-inspired dendritic mesoporous rare-earth nanoparticles potentiate X-ray-triggered reactive oxygen generation for low-dose radiotherapy-radiodynamic therapy - PubMed
6 hours ago
- #Tumor Hypoxia
- #Nanoparticles
- #Radiotherapy
- Development of NK cell-inspired nanoparticles for low-dose radiotherapy-radiodynamic therapy.
- Nanoparticles enhance X-ray absorption, generate oxygen to alleviate tumor hypoxia, and improve therapy efficacy.
- Dual mechanism: enhances hydroxyl radical generation for radiotherapy and singlet oxygen for radiodynamic therapy.
- Superior anticancer outcomes through lipid peroxidation, mitochondrial dysfunction, and DNA double-strand break.
- Potential strategy to minimize systemic toxicity while intensifying tumor suppression with low-dose X-ray.