Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of diabetic kidney disease (DKD) - PubMed
5 hours ago
- #Therapeutic Strategies
- #PPARs
- #Diabetic Kidney Disease
- Diabetic kidney disease (DKD) is a major microvascular complication of diabetes and a leading cause of chronic kidney disease and end-stage renal disease.
- Peroxisome proliferator-activated receptors (PPARs), including PPARα, PPARγ, and PPARβ/δ, are nuclear hormone receptors that regulate genes involved in energy metabolism, differentiation, inflammation, and cellular development.
- This review adopts a cell-type-specific perspective, detailing the roles of all three PPAR isotypes in key renal cell types such as podocytes, mesangial cells, and tubular cells in DKD pathogenesis.
- It explores the potential impact of PPAR genetic polymorphisms on DKD susceptibility.
- The review proposes innovative therapeutic strategies, including PPAR-based multi-target synergistic approaches and nanotechnology-driven cell-specific targeted therapy, to overcome current treatment bottlenecks.