Novel approaches to modulate CAR-T cell function by targeting the tumor microenvironment in ovarian cancer - PubMed
5 hours ago
- #Ovarian cancer
- #Tumor microenvironment
- #CAR-T therapy
- Ovarian cancer (OC) has a poor survival rate, necessitating innovative treatments like CAR-T cell therapy.
- CAR-T therapy faces challenges in ovarian cancer due to its immunosuppressive tumor microenvironment (TME).
- This review examines how the TME inhibits CAR-T function and strategies to overcome these barriers.
- Strategies include next-generation CAR engineering, combination therapies, and TME-modulating technologies.
- The goal is to translate CAR-T therapy into effective clinical treatments for ovarian cancer.