The integrated stress response promotes immune evasion through lipocalin 2 - PubMed
4 days ago
- #immune evasion
- #ATF4-LCN2 axis
- #cancer immunotherapy
- The integrated stress response (ISR) helps cancer cells evade immune detection through lipocalin 2 (LCN2).
- Loss of ATF4 (a key ISR transcription factor) slows tumor growth in immunocompetent mice by boosting T cell responses.
- LCN2, regulated by ATF4, promotes immunosuppressive macrophage infiltration and T cell exclusion in tumors.
- Anti-LCN2 antibodies enhance anti-tumor immunity in aggressive solid tumor models.
- LCN2 levels correlate with reduced T cell infiltration in lung and pancreatic cancer patients.
- The ATF4-LCN2 axis is a potential immunotherapy target to overcome immune evasion.