The nuclear receptor TR4 orchestrates cytoskeletal organization in a Gα12/ROCK-dependent manner to promote myofibroblast differentiation and tissue fibrosis in systemic sclerosis - PubMed
2 hours ago
- #fibrosis
- #nuclear receptor
- #systemic sclerosis
- TR4, a nuclear receptor, is upregulated in fibroblasts of systemic sclerosis (SSc) patients and mouse models.
- TR4 promotes myofibroblast differentiation and tissue fibrosis through Gα12/ROCK-dependent cytoskeletal remodeling.
- Knockdown or fibroblast-specific knockout of TR4 prevents fibrosis in experimental skin and pulmonary models.