Amyloid precursor protein is a subunit of microglial Hv1 channels - PubMed
12 hours ago
- #Alzheimer's disease
- #neuroinflammation
- #microglia
- Amyloid precursor protein (APP) is a subunit of microglial Hv1 proton channels.
- Hv1 channels regulate microglial activation, proton extrusion, ROS production, pH homeostasis, and pro-inflammatory signaling.
- Dysregulated Hv1 activity contributes to neuroinflammation and CNS pathologies.
- APP and its C99 fragment co-assemble with Hv1, enhancing channel activity and inflammatory mediator release.
- Alzheimer's disease-associated APP mutations further potentiate Hv1 activity, linking genetic risk to microglial dysfunction.
- Hv1 channels, previously thought to be homodimers, exhibit functional diversity through accessory subunit incorporation.
- APP-Hv1 is proposed as a new therapeutic target for neuroinflammatory diseases.