The spatiotemporal dynamics of postnatal vascularization in the mouse brain - PubMed
5 hours ago
- #Vascular Remodeling
- #Spatial Transcriptomics
- #Postnatal Brain Development
- Researchers developed LAMBADA, a resource for high-temporal-resolution imaging and aligned spatial transcriptomics of cleared mouse brains.
- Three distinct, brain-wide phases of postnatal cerebral vascular development were identified: isometric expansion, regional specialization, and refinement.
- The phases correlate vascular remodeling with neuronal maturation and synaptogenesis, revealing molecular and structural mechanisms.
- The atlas provides a foundation for studying developmental neurovascular interactions and postnatal brain development.