Chemotherapy induces an IL1β-dependent neutrophil recruitment and activation that promote chemoresistance in metastatic ovarian cancer - PubMed
4 hours ago
- #IL1β pathway
- #chemotherapy resistance
- #neutrophil recruitment
- Chemotherapy in metastatic ovarian cancer (HGSC) increases IL1β expression primarily from myeloid cells, leading to neutrophil recruitment and activation in the tumor microenvironment.
- Neutrophil accumulation and NET formation, driven by IL1β signaling, reduce chemosensitivity; depleting neutrophils or disrupting IL1β/IL1R1 axis improves tumor control and enhances CD8+ T-cell responses.
- IL1R1 is mainly expressed by tumor-associated fibroblasts, and disrupting it decreases CXCL2 levels, reducing neutrophil recruitment and chemoresistance, similar trends are observed in post-chemotherapy human HGSC samples.