Folinic Acid Improves Healing of Diabetic Foot Ulcers - PubMed
3 days ago
- #diabetic foot ulcer
- #folinic acid
- #wound healing
- Folinic Acid Wound Treatment (FAWT) significantly improved healing of chronic diabetic foot ulcers (DFUs) in a double-blind RCT.
- FAWT group showed 88% DFU area reduction compared to 40% in the Control group after 12 weeks.
- Proteomic analysis revealed decreased levels of HMGB1 and activated IL-1B proteins post-FAWT.
- FAWT also reduced phosphorylation of SAP/JNK3 and p38 MAPK, suggesting decreased proinflammatory gene expression.
- Genomic DNA-methylation analysis indicated FAWT-induced decreased methylation at regulatory sites for anti-inflammatory microRNAs.
- FAWT may facilitate DFUs' transition from inflammation to wound repair by inhibiting MAPK-signalling pathways.
- The study suggests FAWT promotes re-epithelialization by modulating inflammatory responses and enhancing keratinocyte function.