Clinical research progress and challenges of vaccine for human papillomavirus-associated cancers - PubMed
4 hours ago
- #clinical trials
- #HPV vaccines
- #cervical cancer
- Cervical cancer, a major cause of cancer-related morbidity in women, is strongly linked to chronic high-risk HPV infection.
- Prophylactic and therapeutic HPV vaccines show progress in clinical trials, but future challenges include type replacement and implications for long-term efficacy.
- Gender-inclusive vaccination is increasingly necessary due to rising HPV-related oropharyngeal cancers, expanding the scope to pan-gender and pan-cancer considerations.
- Next-generation vaccine strategies, such as chimeric VLPs, L2-based vaccines, and heterologous prime-boost regimens, should be accelerated into clinical trials to overcome implementation barriers.
- This review provides a comprehensive perspective and forward-looking roadmap for immunotherapy of HPV-related malignancies.