Intestinal obstruction impairs feeding and promotes sleep in Drosophila melanogaster - PubMed
3 hours ago
- #intestinal obstruction
- #feeding behavior
- #sleep regulation
- Intestinal obstruction (hindgut blockage) in Drosophila melanogaster prevents meconium excretion.
- Flies with intestinal obstruction avoid food, reducing feeding initiation after eclosion.
- Intestinal blockage increases proboscis extension sleep, altering sleep/wake states.
- Experimental inhibition of excretion replicates impaired feeding and increased sleep phenotypes.
- Mechanistic link uncovered: intestinal clearance coordinates feeding, sleep, and survival.
- Potential implications for understanding similar processes across species, including human gut obstruction.