A bioinspired anisotropic anti-inflammatory scaffold enhances spinal nerve regeneration and neural circuit reconstruction via FGF13/Ca2+/CaMK2A/CREB pathway - PubMed
6 hours ago
- #spinal cord injury
- #bioinspired scaffold
- #neural regeneration
- A bioinspired anisotropic anti-inflammatory scaffold enhances spinal nerve regeneration and neural circuit reconstruction via the FGF13/Ca2+/CaMK2A/CREB pathway.
- The scaffold is developed using gelatin methacryloyl (GelMA) hydrogel with N-acetylcysteine-modified silver nanowires (NAC-AgNWs), mimicking the spinal cord's electromechanical microenvironment.
- It features axially aligned microchannels, tunable mechanical strength, and conductivity similar to native spinal tissue.
- In a rat model of complete spinal cord transection, the scaffold showed dual therapeutic effects: early-stage anti-inflammatory modulation and sustained neural reconstruction.
- Transcriptomic analyses identified the FGF13/Ca2+/CaMK2A/CREB axis as key for neurite outgrowth and neural circuit reconstruction.
- This biomaterial design offers a novel therapeutic approach for spinal cord injury repair, combining structural guidance, immunomodulation, and pro-regenerative signaling activation.