Uev1A counteracts oncogenic Ras stimuli in both polyploid and diploid cells - PubMed
5 hours ago
- #Oncogenic Ras
- #Colorectal Cancer
- #Uev1A
- Oncogenic Ras induces DNA replication stress, leading to cellular senescence or death, but can also trigger polyploid Drosophila ovarian nurse cells to die via aberrant division stress.
- A genome-wide genetic screen identified Uev1A as a key protector against oncogenic Ras-induced nurse cell death.
- Uev1A collaborates with the E3 APC/C complex to mediate proteasomal degradation of Cyclin A, a cyclin driving cell division.
- Uev1A and its human homologs (UBE2V1/2) counteract oncogenic Ras-driven tumorigenesis in diploid cells, suppressing tumor overgrowth in Drosophila and human colorectal tumor xenografts.
- Elevated UBE2V1/2 expression correlates with improved survival in colorectal cancer patients with oncogenic KRAS mutations, suggesting therapeutic potential.