Modulation of mitochondrial quality by exercise mimetics: A potential strategy for the prevention and treatment of Alzheimer's disease - PubMed
3 days ago
- #Alzheimer's disease
- #mitochondrial dysfunction
- #exercise mimetics
- Mitochondrial quality decline is a key feature in Alzheimer's disease (AD), affecting energy metabolism, biogenesis, dynamics, and mitophagy.
- Mitochondrial dysfunction worsens amyloid-β (Aβ) deposition and tau hyperphosphorylation, accelerating AD progression.
- Physical exercise improves mitochondrial quality and may slow AD via AMPK and SIRT1 pathways, but may not be feasible for all patients.
- Exercise mimetics, compounds mimicking exercise effects, offer a promising alternative to enhance mitochondrial quality in AD.
- The review explores exercise mimetics' role in mitochondrial homeostasis and their potential as a therapeutic strategy for AD.