Oxycodone versus Sufentanil for Postoperative Analgesia and Early Recovery After Radical Gastrectomy: A Propensity Score-Matched Study - PubMed
6 hours ago
- #Postoperative Analgesia
- #Early Recovery
- #Gastrectomy
- Oxycodone-based patient-controlled intravenous analgesia (PCIA) significantly improved early postoperative pain scores at rest and during movement at 2 hours after radical gastrectomy compared to sufentanil.
- Patients receiving oxycodone required fewer rescue analgesics and experienced faster recovery of gastrointestinal function, including shorter time to first flatus and defecation, and reduced nasogastric tube indwelling time.
- The oxycodone group showed reduced immune suppression postoperatively, with higher lymphocytes, CD4+ T cells, and CD4+/CD8+ T cell ratio, and lower CD8+ T cells on postoperative days 1 and 3.
- Oxycodone was associated with a lower incidence of nausea, shorter hospital stays, and no significant interaction effects in subgroup analyses by age, surgical technique, or resection extent.
- The study concluded that oxycodone-based PCIA offers advantages over sufentanil in pain management, immune response, and recovery for patients undergoing radical gastrectomy.