Hypertriglyceridemia Does Not Worsen Thoracic Aortic Aneurysm and Dissection in GPIHBP1 Knockout Mice - PubMed
7 hours ago
- #hypertriglyceridemia
- #GPIHBP1 knockout mice
- #aortic aneurysm
- Hypertriglyceridemia does not worsen thoracic aortic aneurysm and dissection (TAAD) in GPIHBP1 knockout mice.
- No significant differences in TAAD incidence, mortality, or aortic segment involvement were found between GPIHBP1 knockout and wild-type mice.
- Histopathologic and molecular analyses showed similar levels of elastin fragmentation, ECM degradation, and inflammation in both genotypes.
- Results were consistent across sexes and different dosing regimens of β-aminopropionitrile.
- Hypertriglyceridemia does not exacerbate β-aminopropionitrile-induced TAAD in GPIHBP1-deficient mice.