Modeling aging in a culture dish: towards the development of more sophisticated in vitro models of human skin aging - PubMed
5 hours ago
- #skin-aging
- #3D-skin-equivalents
- #in-vitro-models
- Human skin experiences a decline in functions like barrier protection, immunity, and wound healing with age.
- Skin aging is influenced by both intrinsic (chronological) and extrinsic factors (UV radiation, pollutants, diet).
- Advanced in vitro models are needed to study human-specific skin aging mechanisms due to differences between humans and animal models.
- Current in vitro approaches include 3D systems like full-thickness skin equivalents, organoids, and microphysiological platforms.
- These models help dissect aging biology and support the development of therapeutic and preventive strategies.