eIF3e-mediated translational checkpoint maintains immune tolerance and prevents lymphoid malignancy - PubMed
6 hours ago
- #immunology
- #lymphoma
- #translation control
- Deletion of Eif3e in B cells leads to lymphoproliferation and malignant transformation of bystander lymphocytes.
- Eif3e-deficient B cells upregulate CD80, activating CD4+ T cells that become IL-4-producing TFH-like cells.
- Activated T cells stimulate bystander B cells, creating a feedforward loop of lymphocyte activation.
- Despite hyperactivation, Eif3e-deficient B cells show impaired proliferation, survival, and differentiation.
- The aberrant immune activation drives lymphoma in Eif3e-sufficient lymphocytes, revealing an eIF3e-mediated translational checkpoint for immune tolerance and cancer prevention.