From glucosuria to dialysis: a case report of osmotic nephropathy due to an SGLT2 inhibitor - PubMed
7 days ago
- #Osmotic nephropathy
- #SGLT2 inhibitors
- #Acute kidney injury
- Osmotic nephropathy is a rare drug-induced complication linked to SGLT2 inhibitors like empagliflozin.
- A 49-year-old man with diabetes and hypertension developed acute kidney injury after chronic empagliflozin use, requiring dialysis.
- Renal biopsy confirmed osmotic nephropathy, characterized by tubular vacuolization due to hyperosmolar intratubular pressure from glucosuria.
- Management involves discontinuing the offending drug and supportive care; SGLT2 inhibitors should be paused during dehydration or diarrhea.
- Predisposing factors include diabetes, advanced age, and pre-existing kidney impairment.