Multi-omic identification of key transcriptional regulatory programs during endurance exercise training in rats - PubMed
5 hours ago
- #multi-omics
- #transcriptional regulation
- #endurance exercise
- Integrated multi-omic analysis of chromatin accessibility, DNA methylation, mRNA expression, protein abundance, and phosphorylation in eight tissues of fifty rats following endurance exercise training.
- Identified tissue-specific transcriptional regulatory programs and transcription factor motif enrichment linked to endurance exercise training.
- Discovered distinct regulatory mechanisms: epigenomic alterations facilitating transcription factor access and changes in transcription factor expression or activity.
- Highlighted transcription factors whose target genes are enriched among differentially expressed genes correlated with exercise-related phenotypic changes.
- Revealed unique gene regulatory mechanisms mediating diverse transcriptional responses to endurance exercise across different tissues.