Neutrophil-Driven Cascade-Targeted Nanocarriers Restore Mitochondrial Homeostasis to Ameliorate Renal Ischemia-Reperfusion Injury - PubMed
5 hours ago
- #nanomedicine
- #acute kidney injury
- #mitochondrial therapy
- Developed NKN-LNP, a neutrophil-driven cascade-targeted nanocarrier to treat renal ischemia-reperfusion injury (IRI).
- NKN-LNP first targets neutrophils to cross the glomerular barrier, then releases nanoparticles in response to MMP-2/9 to bind KIM1 on tubular cells.
- Delivers β-nicotinamide mononucleotide (NMN) to activate the NAD+-SIRT3 signaling axis, restoring mitochondrial homeostasis.
- Ameliorates acute kidney injury in mice and shows antifibrotic effects to prevent progression to chronic kidney disease.