TRAP5 Inhibition Targeting Scar-Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition - PubMed
5 hours ago
- #AKI-CKD transition
- #TRAP5
- #Macrophages
- TRAP5 inhibition targets scar-associated macrophages (SMs) to improve the transition from acute kidney injury (AKI) to chronic kidney disease (CKD).
- Single-cell RNA sequencing identified TRAP5+ SMs as key players in maladaptive kidney remodeling during AKI-CKD transition.
- Pharmacological inhibition of TRAP5 reduced fibrosis, inflammation, and renal dysfunction in multiple CKD models, including AAI and ischemia-reperfusion injury (IRI).
- TRAP5 blockade disrupted osteopontin (Spp1)-driven metabolic and profibrotic reprogramming in bone marrow-derived macrophages (BMDMs).
- TRAP5+ SMs were found in both murine and human CKD biopsies, suggesting a conserved pathological role.
- The study highlights TRAP5 inhibition as a promising therapeutic strategy to prevent CKD progression.