Lactate-Induced H3K18 Lactylation by p300 Promotes Odontogenic Differentiation of Human Dental Pulp Stem Cells via WNT5A/Ca2+ Signalling Pathway: A Laboratory Investigation - PubMed
5 hours ago
- #epigenetics
- #dental regeneration
- #WNT signaling
- Lactate-induced H3K18 lactylation by p300 promotes odontogenic differentiation of human dental pulp stem cells (hDPSCs).
- The study identifies WNT5A as a target gene whose promoter shows increased H3K18la enrichment upon lactate treatment.
- Lactate upregulates WNT5A expression and activates the WNT5A/Ca2+ signaling pathway via p300-mediated H3K18la, accelerating odontogenic differentiation.
- In vivo evidence shows lactate administration promotes pulp-like tissue regeneration and increases hDPSC odontogenic marker expression.
- The findings suggest novel strategies for dental pulp regeneration through metabolic, epigenetic, and signaling pathway crosstalk.