Intravenous thrombolysis for acute central retinal artery occlusion: Protocol for a systematic review and individual participant data meta-analysis of randomized controlled trials - PubMed
14 hours ago
- #thrombolysis
- #retinal-artery-occlusion
- #systematic-review
- Study focuses on intravenous thrombolysis (IV) for acute central retinal artery occlusion (CRAO).
- Objective is to determine if IV thrombolysis improves visual outcomes when administered within 4.5 hours of symptom onset.
- Systematic review and individual participant data meta-analysis of randomized controlled trials (RCTs).
- Primary endpoint: final best corrected visual acuity (BCVA) ≥20/63.
- Secondary endpoints include visual field function, disability scores, and safety outcomes like hemorrhage.
- Study registered in PROSPERO (#1154900) and follows rigorous methodology.
- Results may influence guidelines and treatment protocols for CRAO.