Circulating metabolites associated with psoriasis in the UK Biobank and the HUNT Study: A cross-sectional study of 470,352 participants - PubMed
5 hours ago
- #biomarkers
- #metabolomics
- #psoriasis
- Study identifies circulating metabolites associated with psoriasis in a cross-sectional analysis of 470,352 White/European individuals from UK Biobank and HUNT Study.
- After adjusting for covariates, only Glycoprotein acetyls (GlycA) remained significantly associated with psoriasis in both cohorts.
- Severe psoriasis showed more pronounced metabolic changes compared to non-severe psoriasis.
- Phenylalanine levels were highly elevated in psoriatic arthritis versus cutaneous psoriasis, suggesting it as a biomarker for joint involvement.
- Psoriasis exhibited a distinct metabolomic profile compared to other immune-mediated inflammatory diseases like atopic dermatitis.