Neuro-bone-skin tri-regeneration via a microenvironment-responsive PRP-loaded chitosan hydrogel for traumatic brain injury therapy - PubMed
5 hours ago
- #traumatic-brain-injury
- #hydrogel
- #angiogenesis
- Development of CO@P, a microenvironment-responsive PRP-loaded chitosan hydrogel for TBI therapy.
- CO@P demonstrated stability, sustained release, and biocompatibility in vitro.
- Protected N2a cells, reduced M1 polarization, and enhanced BMSC and HUVEC migration.
- In vivo application in TBI mice showed gradient release of growth factors, preventing burst release.
- Modulated inflammation, accelerated neurogenesis, angiogenesis, and improved functional recovery.
- Transcriptomic sequencing confirmed upregulation of regenerative genes and downregulation of pro-inflammatory genes.
- Enhanced scalp wound healing and potent osteogenic effect in cranial defects.
- Offers a novel integrated therapeutic strategy for TBI sequelae.