Structure and function of the synaptonemal complex - PubMed
5 hours ago
- #chromosome segregation
- #synaptonemal complex
- #meiosis
- The synaptonemal complex (SC) is a protein structure that forms between homologous chromosomes during meiosis, crucial for regulating recombination and segregation.
- Once seen as a static electron-dense scaffold, the SC is now understood as a dynamic signaling platform that coordinates key meiotic processes.
- Recent advances have expanded knowledge of SC components and their interaction networks, revealing conservation in structural organization and ancient molecular modules.
- The SC couples its structure to crossover regulation and implements feedback mechanisms controlling DNA break formation and repair to ensure accurate chromosome segregation.