A Self-Immunoregulatory Nanosensitizer for Sonodynamic Cancer Therapy - PubMed
6 hours ago
- #Sonodynamic Therapy
- #Nanoparticles
- #Immunotherapy
- The study identifies immune resistance as a common side effect in clinically used sonodynamic therapy (SDT) sensitizers.
- POR-BG@Alb, a porphyrin-biguanide-loaded albumin nanoparticle, serves as a self-immunoregulatory sonosensitizer.
- POR-BG@Alb disrupts mitochondria, activates AMPK, suppresses c-MYC, and reduces PD-L1 and CD47 levels.
- Unlike traditional sensitizers that increase PD-L1/CD47 post-SDT, POR-BG@Alb enhances T-cell killing and macrophage phagocytosis.
- In multiple cancer models, POR-BG@Alb-mediated SDT reduces tumors, induces systemic antitumor effects, and extends survival.