Immunometabolic resistors of aging in long-lived golden spiny mice - PubMed
6 hours ago
- #immunometabolism
- #aging
- #longevity
- Long-lived golden spiny mice (Acomys russatus) resist functional decline and show reduced senescence in immune-metabolic organs compared to their sister species, Acomys dimidiatus.
- Aged A. russatus maintains transcriptional integrity similar to young mice, highlighting key checkpoints for inflammation and mortality.
- Elevated levels of clusterin in A. russatus macrophages help restrain inflammaging and enhance health span in aged mice.
- The study suggests that A. russatus biology reveals potential therapeutic targets to maintain or enhance function during aging.