Bisdemethoxycurcumin extends lifespan and healthspan in Caenorhabditis elegans via modulation of EGFR-linked signaling pathways - PubMed
2 days ago
- #lifespan-extension
- #EGFR-signaling
- #healthspan
- Bisdemethoxycurcumin (BDMC) extends lifespan and healthspan in C. elegans.
- BDMC shows higher solubility and stability compared to curcumin.
- Optimal lifespan extension (17.7%) observed at 100 μM BDMC.
- Mid-life BDMC intervention extends lifespan by 24.2%.
- BDMC enhances heat stress resistance and improves healthspan markers like locomotion and fertility.
- Reduces senescence-associated β-galactosidase activity and lipid accumulation.
- EGFR identified as a key target via network pharmacology.
- Mechanisms validated through RNA interference, qRT-PCR, molecular docking, and simulations.
- BDMC modulates EGFR-related signaling pathways for healthy aging.