Cohort profile: The DIabetes and ST-segment Elevation Myocardial Infarction (DISTEMI) Study - PubMed
5 hours ago
- #Diabetes mellitus
- #Cardiovascular function
- #STEMI
- The DISTEMI study focuses on humans with type 2 diabetes and/or metabolic dysfunction-associated steatotic liver disease (MASLD) who are at higher risk of ST-segment elevation myocardial infarction (STEMI).
- Primary objective: Detect changes in glycemia and insulin sensitivity from oral glucose tolerance test (OGTT) and their relationship to cardiac function.
- Secondary objectives: Address tissue-specific insulin sensitivity and organ function, focusing on adipose tissue, liver, and heart.
- Exploratory objectives: Include multiomic analyses, measures of mitochondrial function, and quality of life assessments.
- Participants undergo comprehensive cardiometabolic phenotyping at 2 and 12 months post-STEMI, including OGTT, modified Botnia clamp-test, and various MRI techniques.
- Multiomics analyses aim to detect biomarkers for cardiovascular disease risk stratification.
- Currently, 100 participants have been included, with 29% having type 2 diabetes.
- The study integrates cardiometabolic phenomic and multiomic profiling to identify STEMI subtypes and improve precision risk stratification.