Sympathetic nerve-fibroblast crosstalk drives nerve injury, fibroblast activation, and matrix remodeling in pancreatic cancer - PubMed
a day ago
- #Pancreatic Cancer
- #Cancer-Associated Fibroblasts
- #Sympathetic Nerves
- Sympathetic nerve-fibroblast crosstalk plays a critical role in pancreatic cancer progression.
- Sympathetic nerves influence the tumor microenvironment (TME), including interactions with cancer-associated fibroblasts (CAFs).
- Selective elimination of pancreatic sympathetic nerves reduced tumor size in female mice.
- Co-culture systems showed that sympathetic signaling enhances CAF activation and extracellular matrix remodeling.
- Activated CAFs induce transcriptional programs in sympathetic neurons linked to nerve injury response.
- CAFs mediate the tumor-supportive role of sympathetic nerves in pancreatic cancer.