Brain-wide mapping of oligodendrocyte organization, oligodendrogenesis, and myelin injury - PubMed
2 days ago
- #myelin
- #brain-mapping
- #oligodendrocyte
- Brain-wide mapping of oligodendrocyte organization, oligodendrogenesis, and myelin injury in the mouse brain.
- Development of a cellular mapping pipeline using tissue clearing, lightsheet microscopy, and AI-assisted analysis.
- Identification of millions of oligodendrocytes and assessment of regional myelin density.
- Discovery of age- and region-specific differences in oligodendrocyte patterning.
- Integration with transcriptomic and ultrastructural datasets to understand underlying mechanisms.
- Identification of regions with enhanced oligodendrocyte resilience and vulnerability in disease models.
- Observation of white matter injury near β-amyloid plaques in Alzheimer's disease models.
- Demonstration of the pipeline's utility for studying oligodendrocyte dynamics in health and disease.