Targeting the osteoporotic bone microenvironment: Mechanistic insight and therapeutic biomaterials for accelerating bone regeneration - PubMed
7 hours ago
- #osteoporosis
- #biomaterials
- #bone regeneration
- Osteoporotic bone defects (OBD) pose a significant clinical challenge due to a pathological bone microenvironment that hinders regeneration.
- The review introduces a component-centric taxonomy for biomaterials, categorizing them as ion-releasing, metabolite-based, ECM-mimetic, and cytokine-loaded systems.
- These biomaterials are designed to actively modulate the pathological niche by addressing cellular dysfunction and immune-metabolic dysregulation.
- The review highlights the potential of bone organoids and artificial intelligence (AI) in improving preclinical models.
- The work aims to integrate biological understanding with engineering innovation to develop effective regenerative strategies targeting the bone microenvironment.