The shared mechanisms and potential diagnostic markers for IgA nephropathy and celiac disease - PubMed
3 days ago
- #diagnostic markers
- #shared mechanisms
- #autoimmune disorders
- IgA nephropathy (IgAN) and celiac disease (CeD) are autoimmune disorders with dysregulated immune responses.
- Transcriptomic datasets from IgAN and CeD were analyzed using differential expression, WGCNA, functional enrichment, and machine learning.
- ITGB2, CD74, and KLK1 were identified as shared biomarkers with strong diagnostic performance (AUC > 0.7, combined model AUC > 0.9).
- These biomarkers are linked to immune dysregulation and disease progression.
- Four candidate therapeutic agents were predicted for potential treatment strategies.
- The study provides insights into shared pathogenic mechanisms and therapeutic approaches for IgAN and CeD.