Ferroptosis promotes aortic stenosis through 5-lipoxygenase - PubMed
4 hours ago
- #5-lipoxygenase
- #ferroptosis
- #aortic stenosis
- Intra-leaflet hemorrhage in calcified aortic valves contributes to iron overload and ferroptosis, promoting aortic stenosis.
- The arachidonate 5-lipoxygenase (ALOX5)-ACSL4 axis is identified as a central pathway in valvular ferroptosis, driving lipid peroxidation and calcification.
- Inhibition of ALOX5 reduces valve thickness and improves hemodynamic function in experimental models, suggesting a druggable target for treating calcific aortic valve disease.
- Elevated arachidonic acid levels, linked to ferroptosis, independently predict aortic valve calcification and incident aortic stenosis in large population cohorts (SCAPIS and UK Biobank).