Non-canonical IL‑22 receptor signaling remodels the oral mucosal barrier during Candida albicans immunosurveillance - PubMed
6 hours ago
- #IL-22 signaling
- #oral mucosal barrier
- #Candida albicans
- Fungal-induced immunosurveillance enhances resistance to Candida albicans outgrowth and invasion by remodeling the oral mucosal epithelial barrier in mouse models.
- Epithelial remodeling depends on IL-22 and STAT3 signaling via a non-canonical receptor complex of gp130, IL-22Rα1, and IL-10Rβ.
- Epithelial proliferation boosts antifungal defenses by upregulating antimicrobial peptide expression.
- This immunosurveillance-induced epithelial remodeling is specific to the oral mucosa and resets once fungal-specific immunity develops.
- The study identifies transient mucosal remodeling as a key factor in resisting mucosal fungal infection during early colonization.