Platelet-rich plasma-primed bone marrow mesenchymal stem cell-derived exosomes inhibit neuronal apoptosis and autophagy, and promote nerve regeneration via the miR-29a-3p/PTEN/PI3K/Akt/mTOR axis after
3 hours ago
- #miR-29a-3p
- #spinal cord injury
- #exosomes
- PRP-primed BMSC-derived exosomes (PRP-BMSCs-EXO) show superior therapeutic effects for spinal cord injury compared to PRP or BMSC exosomes alone.
- PRP priming enhances BMSC proliferation and exosome secretion, with miR-29a-3p being the most abundant miRNA in these exosomes.
- PRP-BMSCs-EXO delivers miR-29a-3p to inhibit neuronal apoptosis and autophagy and promote nerve regeneration by targeting PTEN in the PI3K/Akt/mTOR axis.
- Mechanistic studies confirm the miR-29a-3p/PTEN/PI3K/Akt/mTOR pathway mediates neuroprotection, validated in both in vitro and in vivo SCI models.
- This combined approach represents a promising strategy for SCI treatment, offering enhanced neuroprotective outcomes.